| Bioactivity | CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier[1][2]. |
| Invitro | FAM-CAQK 选择性地与局灶性和撞击引起的脑损伤相关，而不与健康的大脑和其他组织相互作用。在病变部位，肽主要与沉积在反应性星形胶质细胞附近的间质空间中的纤维细胞外基质 (ECM) 相关[1][2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CAQK peptide 相关抗体: |
| In Vivo | CAQK (100 nmoles/100 µL；尾静脉；损伤后 24 小时或 5 天) 定位于急性溶血卵磷脂注射液引起的局灶性脱髓鞘位点。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2088281-24-5 |
| Sequence | Cys-Ala-Glu-Lys |
| Shortening | CAQK |
| Formula | C17H32N6O6S |
| Molar Mass | 448.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Charly Abi-Ghanem, et al. CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries. Front Cell Neurosci. 2022 Aug 22:16:908401. [2]. Aman P Mann, et al. A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries. Nat Commun. 2016 Jun 28:7:11980. |